Variegating rearrangements

These stocks carry chromosomal rearrangements that juxtapose euchromatin and heterochromatin and show variegated expression of the white gene, the brown gene or other genes.

In some of these stocks, variegated gene expression is suppressed by the presence of known Su(var) mutations. In other stocks, variegated expression has become suppressed from the accumulation of unknown modifiers. It is often necessary to cross variegating rearrangements into different genetic backgrounds to see robust variegated gene expression.

  • Rearrangements causing variegated expression of the white gene

    The most commonly used rearrangement causing variegation of white is In(1)w[m4]. Stocks with In(1)w[m4] are shown here. Stocks with other w-variegating rearrangements are shown in the table below.

  • Rearrangements causing variegated expression of the brown gene

    The brown-variegating rearrangement Dp(?;2)bw[D] is present in many stocks. A list is provided here. Stocks with other bw-variegating rearrangements are shown in the table below.

  • Rearrangements causing variegated expression of other genes

    In the case of 'unknown vital gene', the juxtaposition of an unknown euchromatic gene with heterochromatin causes lethality of XO males, but not XY males.