In contrast to MARCM, DMARCM requires two, independent recombination events to initiate expression of the cell marker. This results in low-frequency labeling of cell lineages that is linearly scalable with the length of heat shock. These stocks were published in Snee et al., 2020, Ultra-low frequency labeling of single cell lineages in Drosophila. Dev. Bio. 457(1):9-12.

Comparison of the labeling efficiency of DMARCM and MARCM and the linear scalability of DMARCM.