Seizure disorders/epilepsy

Several types of fly mutants with epileptic phenotypes are currently used in modeling seizures. The so-called "bang-sensitive" mutants exhibit seizures and paralysis upon mechanical stimuli; seizures can be suppressed by the administration of anticonvulsant drugs. Seizure-suppressor mutants include Sh, shakB and para.

Fly stocks in the Bloomington collection that can be used to study seizure disorders and epilepsy are listed here (see also the page for Galphao-related epilepsies).

fly genehuman gene or gene typemutant phenotype in flies
couch potato (cpo)RNA binding protein with multiple splicing 2 (RBPMS2)bang-sensitive
easily shocked (eas)ethanolamine kinase (ETNK1)bang-sensitive
ether a go-go (eag)voltage-gated potassium channels, subfamily H (e.g. KCNH5)bang-sensitive
jitterbug (jbug)filaminsbang-sensitive
kazachoc (kcc)potassium/chloride transporters - solute carrier family 12 (e.g. SLC12A4)bang-sensitive
knockdown (kdn)citrate synthase (CS)bang-sensitive
paralytic (para)voltage-gated sodium channel, type III (SCN3A)temperature-sensitive paralytic
seizure (sei)voltage-gated potassium channel, subfamily H (e.g. KCNH2)temperature-sensitive paralytic
Shaker (Sh)voltage-gated potassium channels, shaker-related (e.g. KCNA3)uncoordinated/behavior defective
shaking B (shakB)gap junction proteinsuncoordinated/behavior defective
julius seizure (jus)transmembrane domain proteinbang-sensitive
slowpoke (slo)large conductance calcium-activated potassium channels (e.g. KCNMA1)temperature-sensitive paralytic
stress-sensitive B (sesB)adenine nucleotide translocator, solute carrier family 25 (e.g. SLC25A4)bang-sensitive
technical knockout (tko)mitochondrial ribosomal protein S12 (MRPS12)bang-sensitive