Machado-Joseph Disease

Machado-Joseph Disease (MJD), also known as Spinocerebellar Ataxia 3 (SCA3), is a progressive disorder characterized by loss of motor coordination, spasticity, and impaired eye movements. MJD is one of several diseases caused by an increase in the number of CAG repeats within the coding region of the disease gene (in this case the ataxin-3/MJD gene) and subsequent translation of those repeats into an expanded polyglutamine (polyQ) tract in the protein. Fly stocks in the Bloomington collection that can be used to study MJD are listed here.

General Information links for Machado-Joseph disease:

General information links for ataxin 3: