Alzheimer disease is the most common cause of degenerative dementia in the elderly. The causes of late-onset Alzheimer disease are unclear; risk factors such as mutations in the APOE gene may be involved. Mutations in three genes have been associated with early-onset Alzheimer disease - APP, PSEN1, and PSEN2. Fly stocks in the Bloomington collection that can be used to study Alzheimer Disease are listed here.
General Information links for Alzheimer disease:
OMIM (see also links in table below)
NIH's Genetics Home Reference - includes links for GHR pages on APOE, APP, PSEN1 and PSEN2