Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) is a progressive neurodegenerative disease associated with degeneration of motor neurons resulting in muscle weakness and atrophy. Fly stocks in the Bloomington collection that can be used to study ALS are listed here.

For stocks to study the expanded GGGGCC repeats in C9orf72, see the page for Frontotemporal dementia and/or Amyotrophic lateral sclerosis.

General information links for ALS:

ALS subtypes with causative genes identified (from OMIM)
SubtypeHuman geneHuman proteinFly gene
ALS1SOD1SOD1 (superoxide dismutase 1)Superoxide dismutase (Sod)
ALS2ALS2AlsinAls2
ALS4SETXsenataxin 
ALS6FUSFUScabeza (caz)
ALS8VAPBVAMP-associated protein B (VAPB)Vap33
ALS9ANGAngiogenin 
ALS10TARDBPTar DNA-binding protein (TARDBP)TBPH
ALS11FIG4FIG4/SAC3FIG4
ALS12OPTNOptineurin 
  • ALS1 - Human SOD1, fly Sod1
  • ALS2 - Human Alsin, fly Als2

  • ALS6 - Human FUS, fly caz
  • ALS8 - Human VAPB, fly Vap33
  • ALS10 - Human TARDBP, fly TBPH
  • ALS11 - Human FIG4/SAC3, fly FIG4