Nonsyndromic X-linked intellectual disability

Approximately 14 causative genes have been identified for nonsyndromic X-linked intellectual developmental disability (XLID). Nonsyndromic intellectual disabilities are typified by a lack of other abnormalities (syndromic X-linked intellectual developmental disabilities are generally accompanied by other specific distinguishing features). Fly stocks in the Bloomington collection that can be used to study XLID are listed here.

General information links for XLID:

  • A list of XLID-associated genes can be found here.
XLID subtypeHuman gene(s) full nameHuman gene(s) symbolFly gene(s)
XLID1IQ motif- and SEC7 domain-containing protein 2IQSEC2schizo (siz) (most similar to IQSEC1)
XLID9FTSJ Homolog 1FTSJ1CG5220
XLID21Interleukin 1 receptor accessory protein-like 1IL1RAPL1
XLID30p21-activated kinase 3PAK3p21-activated kinase (Pak)
XLID63Acyl-CoA synthetase long chain family member 3 and 4ACSL3 and ACSL4Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3)
XLID72Ras-associated protein RAB39BRAB39BRab39
XLID90Discs large, Drosophila, homolog of, 3DLG3dlg1 (most similar to DLG1)
XLID93Bromodomain- and WD repeat-containing protein 3BRWD3BRWD3 (most similar to BWRD1)
XLID-Wu typeGlutamate receptor, ionotropic, AMPA 3GRIA3GluRIA and GluRIB
XLID106O-linked N-acetylglucosamine transferaseOGTsxc
XLID29Aristaless-related homeobox, X-linkedARX