Approximately 14 causitive genes have been identified for non-syndromic X-linked mental retardation (MRX). Non-syndromic intellectual disabilities are typified by a lack of other abnormalities (syndromic X-linked mental retardation or MRXS is generally accompanied by other specific distinguishing features). Fly stocks in the Bloomington collection that can be used to study MRX are listed here.
General information links for MRX:
| MRX subtype | Human gene(s) full name | Human gene(s) symbol | Fly gene(s) |
|---|---|---|---|
| MRX1 | IQ motif- and SEC7 domain-containing protein 2 | IQSEC2 | schizo (siz) (most similar to IQSEC1) |
| MRX9 | FTSJ Homolog 1 | FTSJ1 | CG5220 |
| MRX21/34 | Interleukin 1 receptor accessory protein-like 1 | IL1RAPL1 | |
| MRX30/47 | p21-activated kinase 3 | PAK3 | p21-activated kinase (Pak) |
| MRX63/68 | Acyl-CoA synthetase long chain family member 3 and 4 | ACSL3 and ACSL4 | Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3) |
| MRX72 | Ras-associated protein RAB39B | RAB39B | Rab39 |
| MRX90 | Discs large, Drosophila, homolog of, 3 | DLG3 | dlg1 (most similar to DLG1) |
| MRX93 | Bromodomain- and WD repeat-containing protein 3 | BRWD3 | BRWD3 (most similar to BWRD1) |
| MRX94 | Glutamate receptor, ionotropic, AMPA 3 | GRIA3 | GluRIA and GluRIB |
| MRX106 | O-linked N-acetylglucosamine transferase | OGT | sxc |
| MRXARX | Aristaless-related homeobox, X-linked | ARX |
