Primary microcephaly

Primary microcephaly is characterized by a significantly reduced head circumference likely directly caused by the development of a small, but apparently normally formed brain (see links to subtypes below). All patients are affected mentally. Fly stocks in the Bloomington collection that can be used to study primary microcephaly are listed here.

General information links for Primary microcephaly:

OMIM links for individual subtypes are provided in the table below
a search for "primary microcephaly" in NLM/NIH's Genetics Home Reference will bring up GHR links for several of the genes below

MCPH subtypes with causative genes identified
Microcephaly subtype	Human gene	Fly gene
MCPH1	MCPH1/Microcephalin	Microcephalin (MCPH1)
MCPH2	WDR62	Wdr62
MCPH3	Cdk5rap2 (CDK5 regulatory subunit associated protein 2)	centrosomin (cnn) (but see also Eisman and Kaufman, 2013)
MCPH4	Cep152 (Centrosomal protein 152 kDa)	asterless (asl)
MCPH5	ASPM (Abnormal spindle-like, microcephaly-associated)	abnormal spindle (asp)
MCPH6	CENPJ/CPAP (Centromeric protein J)	Sas-4
MCPH7	STIL (SCL/TAL1 interrupting locus)	ana2
MCPH8	CEP135 (Centrosomal protein, 135-kD)	Cep135

Primary microcephaly

MCPH1 - Human MCPH1, fly MCPH1

MCPH2 - Human WDR62, fly Wdr62

MCPH3 - Human Cdk5rap2, fly cnn

MCPH4 - Human Cep152, fly asl

MCPH5 - Human ASPM, fly asp

MCPH6 - Human CENPJ (aka CPAP), fly Sas-4

MCPH7 - Human STIL, fly ana2

Bloomington Drosophila Stock Center social media channels

Bloomington Drosophila Stock Center social media channels