GNAO1 is the GTP-binding α subunit of the G protein heterotrimer, Go (the "o" stands for "other"). It is the most abundant Gα protein in the brain and several mutations in GNAO1 are associated with epilepsies, movement disorders (e.g. chorea, dystonia) and/or developmental delay.
For additional information see:
Stocks for studying Galphao-related epilepsies, spastic paraparesis and dystonia |
|---|
| Relevant gene in stock | Fly disease model or related mutation or transgene | Stk # | Comments |
|---|---|---|---|
| Galphao | TI{TI}Galphao[KO] | 81098 | This null Galphao allele results from replacing a a 76 bp region just before the 2nd coding exon with a cassette carrying stop codons and lox-P flanked 3xP3-RFP. |
| Galphao | Galphao[G45E] | 81099 | This CRISPR-generated Galphao allele carries amino acid change G45E found in a human GNAO1 variant associated with epilepsy-related symptoms. |
| Galphao | Galphao[A221D] | 81097 | This CRISPR-generated Galphao allele carries amino acid change A221D change found in a human GNAO1 variant associated with spastic paraparesis and dystonia. |
| Galphao | P{TRiP.JF02844}attP2 | 28010 | Expresses dsRNA for RNAi of Galphao (FBgn0001122) under UAS control in the VALIUM10 vector. |
| Galphao | P{TRiP.HMS01129}attP2 | 34653 | Expresses dsRNA for RNAi of Galphao (FBgn0001122) under UAS control in the VALIUM20 vector. |
| Galphao | Mi{PT-GFSTF.2}Galphao[MI06587-GFSTF.2p] | 63179 | Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Galphao tagged with EGFP-FlAsH-StrepII-TEV-3xFlag. |
| Galphao | Mi{PT-GFSTF.1}Galphao[MI00833-GFSTF.1] | 60504 | Recombination Mediated Cassette Exchange of a Mi{MIC} insertion results in expression of Galphao tagged with EGFP-FlAsH-StrepII-TEV-3xFlag. |
| Galphao | P{UAST-YFP.Rab9Fb.S21N}Galphao[01] | 9845 | Expresses a dominant negative, YFP-tagged Rab9Fb protein under UAS control. |
| Galphao | P{UAS-Galphao.Pi}H | 92004 | Expresses a Pertussis insensitive (Pi) G(o)alpha under UASt control. Stock also expresses pertussis toxin subunit 1 precursor, ptxA, under tetO control. |
| Galphao | P{UAS-Galphao.Pi}H | 92007 | Expresses a Pertussis insensitive (Pi) G(o)alpha under UASt control. |
| GNAO1 (human) | PBac{UAS-hGNAO1.HA}VK00033 | 79003 | Expresses HA-tagged human GNAO1 under UAS control. |
