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Transpositions in Bloomington stocks

Transpositions in Bloomington stocks

A transposition is generated by three chromosomal breakpoints and the movement of a chromosomal segment to a new position. A transposition can be separated into deletion and duplication components.

Transposition

Transpositions can be interchromosomal as shown in the figure, or they can be intrachromosomal so that the deletion and duplication components remain linked.

In general, transposition stocks in the Bloomington collection are maintained because the deletion and/or duplication chromosomes are useful for experiments, or because one of the breakpoints disrupts a gene.

The following stocks have deletion and/or duplication components that can be useful in gene mapping, complementation and mutation rescue experiments. These stocks are used more frequently for their duplication components; consequently, they are also listed among cytologically defined duplication stocks.

Symbol	Stk #	Genotype	Breakpts
Tp(1;2)r[+]75c	3217	C(1)M4, y[2]; Tp(1;2)r[+]75c, sl[3]/CyO	14B13;15A9 into 35DE
Tp(1;2)rb[+]71g	909	Tp(1;2)rb[+]71g, ct[6] v[1]/C(1)DX, y[1] f[1]	3F3;5E8 into 23A1-5
Tp(1;2)sn[+]72d	910	Tp(1;2)sn[+]72d, f[1] car[1]/C(1)DX, y[1] f[1]; Dp(?;2)bw[D], bw[D]	7A8;8A5 into 58E
Tp(1;2)v[+]65b	930	Tp(1;2)v[+]65b, lz[50e] v[+65b]/C(1)DX, y[1] w[1] f[1]	9F12-13;11A6-9 into 40-41
Tp(1;2)w-ec	1319	Tp(1;2)w-ec, ec[64d] cm[1] ct[6] sn[3]/C(1)DX, y[1] w[1] f[1]	3C2;3E8 into 37D
Tp(1;3)sta	844	Tp(1;3)sta, sta[1]: ss[sta]/FM3	1E1;2B3-4 into 89C1-2
Tp(1;3)v[+]74c	4245	Tp(1;3)v[+]74c/FM7a	9E3;11B12 into 80-81
Tp(2;3)DX11	4118	Tp(2;3)DX11, l(2)43Bb[3] cn[1] bw[1] speck[1]/CyO, Tp(2;2)pk-sple[26], pk[pk-sple-26]	41;43B1-3 into 80
Tp(2;3)P	1643	Tp(2;3)P, Pale[1], dpy[ov1] Adc[b-1] cn[1] Gull[1]: e[1]/CyO; TM1	58E3-4;60D14-E2 into 96B5-C1
Tp(3;Y)P92	4244	Dp(3;1)P68, y[1]/FM6; Tp(3;Y)P92, p[p] hb[D1]	84D10-11;85A1-3 into Y
Tp(3;Y)ry506-85C	1534	Tp(3;Y)ry506-85C/MKRS	87D1-2;88E5-6 into Y

The following stocks are maintained because at least one transposition breakpoint disrupts a gene.

Symbol	Stk #	Genotype	Breakpts
ss[sta]	844	Tp(1;3)sta, sta[1]: ss[sta]/FM3	1E1;2B3-4 into 89C1-2
sta[1]	844	Tp(1;3)sta, sta[1]: ss[sta]/FM3	1E1;2B3-4 into 89C1-2
dpp[s7]	98356	Tp(2;2)dpp[s7]/CyO	24E1-24E2;25A1-25A2;22F1-22F2
pk[pk-sple-26]	8889	Df(2R)sple-D1, Adc[b-1] cn[1]/CyO, Tp(2;2)pk-sple[26], pk[pk-sple-26]	29F;58E;42F;45A (complex intrachromosomal rearrangement)
pk[pk-sple-26]	44232	pk[sple-4] cn[1] bw[1] speck[1]/CyO, Tp(2;2)pk-sple[26], pk[pk-sple-26]	29F;58E;42F;45A (complex intrachromosomal rearrangement)
pk[pk-sple-26]	4118	Tp(2;3)DX11, l(2)43Bb[3] cn[1] bw[1] speck[1]/CyO, Tp(2;2)pk-sple[26], pk[pk-sple-26]	29F;58E;42F;45A (complex intrachromosomal rearrangement)
pk[pk-sple-26]	4130	In(2R)DX8, Dscam1[17] cn[1] bw[1] speck[1]/CyO, Tp(2;2)pk-sple[26], pk[pk-sple-26]	29F;58E;42F;45A (complex intrachromosomal rearrangement)
Gull[1]	1643	Tp(2;3)P, Pale[1], dpy[ov1] Adc[b-1] cn[1] Gull[1]: e[1]/CyO; TM1	58E3-4;60D14-E2 into 96B5-C1
Pale[1]	1643	Tp(2;3)P, Pale[1], dpy[ov1] Adc[b-1] cn[1] Gull[1]: e[1]/CyO; TM1	58E3-4;60D14-E2 into 96B5-C1
Antp[Ctx]	2251	Tp(3;2)Antp[Ctx], Antp[Ctx] Sb[sbd-2]/TM1	83C8-9;84B2-3 and 84B2-3;85E4-5 into 35B3-4
dpp[s3]	99040	Tp(3;2)dpp[s3]/CyO	22F1-22F2;40C;82A;92A5-92A8
Abd-B[Vno]	3717	Df(1)bb74, y[1] pn[1] cv[1] m[1] f[1]/FM7a; TM2/Tp(3;3)Vno, Abd-B[Vno], Vno[1]; sv[spa-pol]	89E;93F & 93F;94A into 96F11-14
Vno[1]	3717	Df(1)bb74, y[1] pn[1] cv[1] m[1] f[1]/FM7a; TM2/Tp(3;3)Vno, Abd-B[Vno], Vno[1]; sv[spa-pol]	89E;93F & 93F;94A into 96F11-14
mtd[1]	4877	Tp(3;Y)82Fd[1], mwh[1] mtd[1] red[1] e[4]/TM3, Sb[1]	82F3-11;98F8-14 into Y

We have one stock where the transposition is somewhat irrelevant. The stock is maintained for Df(2R)pk78k. The intrachromosomal transposition Tp(2;2)CA30 is present and the deletion and duplication components could potentially be separated and used in experiments, but, basically, it is incidental.

Symbol	Stk #	Genotype	Breakpts
Tp(2;2)CA30	1594	Df(2R)pk78k, Tp(2;2)CA30, speck[1]/CyO	26C1;27D1 into 34A4-34B1

Transpositions in Bloomington stocks

Transpositions useful for their deletion and/or duplication components

Transpositions that cause mutations

Incidental transposition

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