Parkinson disease

Parkinson disease is a progressive neurological disorder resulting from the loss of dopaminergic neurons in the midbrain (largely in the substantia nigra). Symptoms include tremor, loss of balance and motor coordination, rigidity, and slowing of movements. Fly stocks in the Bloomington collection that can be used to study Parkinson disease are listed here.

General information links for Parkinson disease:

Parkinson subtypes with causative genes identified (from OMIM)
subtypeHuman gene symbolHuman gene full nameFly gene
PARK1 and PARK4SNCAalpha-synuclein 
PARK2PARK2Parkinparkin (park)
PARK6PINK1PINK1PTEN-induced putative kinase 1 (Pink1)
PARK7DJ1/PARK7DJ1DJ-1alpha and dj-1beta
PARK8LRRK2Leucine-rich repeat kinase 2/dardarinLeucine-rich repeat kinase (Lrrk)
  • PARK1 and 4 - Human alpha-synuclein
  • PARK2 - Human Parkin, fly parkin
  • PARK6 - Human Pink1, fly Pink1
  • PARK7 - Human DJ1, fly DJ-1alpha and dj-1beta
  • PARK8 - Human LRRK2, fly Lrrk
  • PARK13 - Human HTRA2, fly Htra2