Non-syndromic X-linked mental retardation

Approximately 14 causitive genes have been identified for non-syndromic X-linked mental retardation (MRX). Non-syndromic intellectual disabilities are typified by a lack of other abnormalities (syndromic X-linked mental retardation or MRXS is generally accompanied by other specific distinguishing features). Fly stocks in the Bloomington collection that can be used to study MRX are listed here.

General information links for MRX:

  • A list of MRX-associated genes can be found here.
MRX subtypeHuman gene(s) full nameHuman gene(s) symbolFly gene(s)
MRX1IQ motif- and SEC7 domain-containing protein 2IQSEC2schizo (siz) (most similar to IQSEC1)
MRX9FTSJ Homolog 1FTSJ1CG5220
MRX21/34Interleukin 1 receptor accessory protein-like 1IL1RAPL1
MRX30/47p21-activated kinase 3PAK3p21-activated kinase (Pak)
MRX63/68Acyl-CoA synthetase long chain family member 3 and 4ACSL3 and ACSL4Acyl-CoA synthetase long-chain (Acsl) (most similar to ACSL3)
MRX72Ras-associated protein RAB39BRAB39BRab39
MRX90Discs large, Drosophila, homolog of, 3DLG3dlg1 (most similar to DLG1)
MRX93Bromodomain- and WD repeat-containing protein 3BRWD3BRWD3 (most similar to BWRD1)
MRX94Glutamate receptor, ionotropic, AMPA 3GRIA3GluRIA and GluRIB
MRXARXAristaless-related homeobox, X-linkedARX
  • MRX30/47 - Human PAK3, fly Pak
  • MRX63/68 - HumanACSL3 and ACSL4, fly Acsl
  • MRX72 - Human RAB39B, fly Rab39
  • MRX90 - Human DLG3, fly dlg1
  • MRX93 - Human BRWD3, fly BRWD3
  • MRX94 - Human GRIA3, fly GluRIA and GluRIB