Hereditary spastic paraplegias

1Hereditary spastic paraplegias (SPGs) are a group of neurodegenerative disorders associated with degeneration of corticospinal axons and generally characterized by progressive spasticity in the lower extremities. Fly stocks in the Bloomington collection that can be used to study hereditary spastic paraplegias are listed here.

General information links for Hereditary spastic paraplegia:

SPG subtypes with causative genes identified (from OMIM)
SPG subtypeHuman geneHuman proteinFly gene
SPG1/L1 or MASA syndromeL1CAML1CAMNeuroglian (Nrg)
SPG2PLP1PLP1 and DM20M6
SPG3A/Strumpell diseaseSPG3Aatlastinatlastin (atl)
SPG4SPG4spastinspastin (spas)
SPG5ACYP7B1CYP7B1 
SPG6NIPA1NIPA1spichthycin (spict)
SPG7SPG7parapleginCG2658
SPG8KIAA0196strumpellinStrumpellin
SPG10KIF5AKIF5AKinesin heavy chain (Khc)
SPG11SPG11spatacsinCG13531
SPG13HSPD1Hsp60Hsp60A
SPG15ZFYVE26spastizinCG5270
SPG17/Silver syndromeBSCL2seipinSeipin
SPG20/Troyer syndromeSPG20spartinspartin
SPG21/Mast syndromeACP33maspardin/ACP33 
SPG31REEP1REEP1Reep1
SPG33ZFYVE27ZFYVE27 
SPG42SLC33A1AT1/SLC33A1CG9706
  • SPG1 - Human LICAM, fly Nrg

  • SPG2 - Human PLP1, fly M6
  • SPG3 - Human atlastin, fly atl
  • SPG4 - Human SPG4/spastin, fly spas
  • SPG6 - Human NIPA1, fly spict
  • SPG7 - Human SPG7/paraplegin, fly CC2658
  • SPG10 - Human KIF5A, fly Khc
  • SPG13 - Human Hsp60, fly Hsp60A
  • SPG17 - Human BSCL2/seipin, fly Seipin
  • SPG20 - Human spartin, fly spartin
  • SPG31 - Human REEP1, fly Reep1